The took place in 680-681 a.d. Egypt was under Arab control and the Coptic Church had been estranged since the Council of Chalcedon in 451 a.d., and hence was not represented at this council.

Emperor Constantine IV tried to put an end to the monothelite controversy, which started under Heraclius. Some 174 fathers attended and signed the final statement of the council. In the of this council, Dioscorus of Alexandria and of Antioch were considered among the heretics.