The Second of Constantinople took place in the year 553 a.d. during the reign of Justinian. The council anathematized The Three Chapters (the works of Theodoret and Ibas of Edessa) and condemned, post mortem, of Mopsuestia as the real instigator of . Some 165 bishops attended this council, including five bishops.

The Pope of Rome, Vigilius, was confined and coerced into accepting the decisions of this council, after which he was permitted to return to Rome. Because of these decisions, the bishops of Italy, Illyria, and broke off with Rome for nearly half a century. These decisions did not change the position of the Coptic Church.