It was established in 1974 and the first took place in Nicosia, Cypress, in May 1974. At the beginning it consisted of the Eastern churches, the Orthodox churches, and the Protestant churches. In 1990, the seven churches of the region joined the council. The churches are represented by 94 members, who meet every four years.

The has offices in Amman, Beirut, Cairo, and Limassol. An elected executive with a general secretary is responsible for the administration of the during each interim period. In 2003, Guirgis Saleh, a Coptic theologian and professor, was elected general secretary.